Sina Barazandeh
CMU SCS PhD student building AI agents and machine-learning systems for autonomous laboratories and scientific discovery.

I am a PhD student in the School of Computer Science at Carnegie Mellon University (Computational Biology Department), advised by Dr. Jose Lugo-Martinez.
Most recently, I led CMU’s work using the Model Hardware Standard (MHS) in the limited research preview: I built instrument drivers and orchestration so an AI agent could coordinate a liquid handler, plate reader, robotic arm, and cameras for closed-loop dose-response experiments. Nature covered the work on 24 September 2026.
I am seeking Summer 2027 research and applied-science internships in ML systems, reinforcement learning, simulation, generative AI, and AI agents.
[Resume (PDF)] · [Academic CV (PDF)]
Education
- Ph.D. Computational Biology — School of Computer Science, Carnegie Mellon University (2024–2029)
Advisor: Dr. Jose Lugo-Martinez - M.Sc. Computer Engineering — Bilkent University (2021–2024, GPA: 3.9/4.0)
Advisor: Dr. A. Ercument Cicek · Thesis: Generative Models for Generating and Optimizing Biological Sequences - B.Sc. Computer Engineering — Shiraz University (2016–2021, GPA: 3.5/4.0)
Research Highlights
- Autonomous Laboratories / MHS: Drivers and orchestration for a liquid handler, plate reader, robotic arm, and cameras. Case study
- Simulation & Benchmarking: simPCL, a simulator and benchmark generator for planning and fault recovery in programmable cloud laboratories. I am interested in sim-to-real transfer, reinforcement learning in MuJoCo, and 3D world models for laboratory simulation.
- Generative Models: Sequence design with GANs and seq2seq models (UTRGAN, RNAtranslator, RNAGEN)
- Reinforcement Learning: Policy optimization for biomarker discovery under structure-aware rewards
- ML Systems: FlashAttention and PagedAttention in MiniTorch (LLM Systems coursework)
Recent News
- Sep 2026: Nature News covered the MHS work: AI system helps lab devices ‘talk’ with each other — streamlining research. The article opens in our lab and describes the team’s work with Jose Lugo-Martinez.
- Sep 2026: Presented the poster Agentic Recovery for Orchestration of Programmable Cloud Laboratories at 2026 Predictive Phenomics, Washington, DC (September 22–24).
- Aug 2026: Anthropic’s MHS research preview included this deployment. Serial-dilution dose-response experiments ran ~3× faster. I led the work at CMU. Read the post. Also covered by CMU SCS on LinkedIn and X.
- Contributed talk at the AI Scientist Summer Workshop, Microsoft Research, Cambridge, MA (Aug 2026): Agentic Fault Recovery for Autonomous Orchestration of Programmable Cloud Laboratories
- Poster on simPCL at SciFM 2026 (Chicago, IL)
- Publications in 2025 (PLOS Computational Biology, Bioinformatics Advances) and RNAGEN in ChemBioChem (2026)
- Attended the SenNet Annual Meeting (Washington, DC, 2025) and PathVisions (San Diego, 2025)
See my projects, publications, and CV for more details.